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Anti-Inflammatory Pharmaceutical Raw Materials White Powder Tacrolimus CAS 104987-11-3

Tacrolimus Details 

Product name Tacrolimus
CAS 104987-11-3
MF C44H69NO12
MW 804.02
Melting Point 113-115 C
Boiling Point 871.7 C at 760 mmHg
Appearance White powder
Purity 99.5% min
MOQ 1g
Storage Store in a cool, dry place. Do not store in direct sunlight. Store in a tightly closed container.

Tacrolimus Description
Tacrolimus (trade names Prograf, Advagraf, Protopic) is animmunosuppressive drug used mainly after allogeneic organ transplant to lower the risk of organ rejection. It achieves this by inhibiting the production of interleukin-2, a molecule that promotes the development andproliferation of T cells, which are vital to the body’s learned (or adaptive) immune response. Tacrolimus is also used in the treatment of other T cell-mediated diseases such as eczema (for which it is applied to the skin in a medicated ointment), severe refractory uveitis after bone marrow transplants, exacerbations ofminimal change disease, Kimura’s disease, and the skin condition vitiligo.

Tacrolimus is an immunosuppressive drug whose main use is after organ transplant to reduce the activity of the patient’s immune system and so the risk of organ rejection. It is also used in a topical preparation in the treatment of severe atopic dermatitis, severe refractory uveitis after bone marrow transplants, and the skin condition vitiligo. It was discovered in 1984 from the fermentation broth of a Japanese soil sample that contained the bacteria Streptomyces tsukubaensis. Tacrolimus is chemically known as a macrolide. It reduces peptidyl-prolyl isomerase activity by binding to the immunophilin FKBP-12 (FK506 binding protein) creating a new complex. This FKBP12-FK506 complex interacts with and inhibits calcineurin thus inhibiting both T-lymphocyte signal transduction and IL-2 transcription.

Tacrolimus Test Report 

Tests Specifications Results
Description A white or off-white crystalline powder Conform
Identification 1. IR (USP <197K>) Conform
2. HPLC retention times Conform
Water (USP <921> Method I) 1.6 ~ 3.0% 2.1%
Residue on ignition (USP <281>) <0.2% 0.08%
Heavy metals (USP <231> II) <20 ppm < 20 ppm
Related substances (In-house HPLC method) Ascomycin 0.8% 0.064%
Residual solvents (In-house method) Acetone 2000 ppm Not detected
Assay (on anhydrous basis) 98.0% ~ 102.0% 100.0%
Conclusion: Complied with In-House standard

Wumei Advantage

Quality All steroids with Lab Test Report (COA available), Purity reach 98%min
Shipping Time Super fast delivery, parcel could deliver out worldwide within 12 hours, door to door around 3-7 days.
Delivery Safety shipping guarantee, If the parcel is seized / lost / damaged, same product will resend free for you immediately.

Purchase Guide
1. Lead Time: Within 12hours after you payment
2. Delivery Time: 3-7 days door to door
3. Packing: Super discreet (hundreds to choose from)
4. Shipping: DHL / TNT / UPS / HKEMS / FedEx / etc.
5. Tracking number: Available after parcel deliver out.
6. After-sales service: 24/7 online

Steroids Manufacturer Contacts

Email: ying@wumeitech.com
Skype: ying_2073
Wechat: lindayin1225
Tel/Whatsapp: +86-17707567122

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